Glossary
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Terms used on this site.
Montreal Cognitive Assessment (MoCA)
For a clinician. A brief bedside screen of attention, memory, language, visuospatial skill, and orientation. Clinicians use the total and domain scores as a screen.
For a general reader. A short set of thinking tasks. A lower score means more trouble with those tasks.
mild cognitive impairment (MCI)
For a clinician. A clinical syndrome: cognitive decline beyond typical aging, with largely preserved independence.
For a general reader. A person notices more thinking trouble than before, but still handles most daily life. Some people later develop dementia.
cascade tier
For a clinician. An ordered severity band in the published cascade analysis. Tiers group similar domain profiles for progression models.
For a general reader. A step on a ladder of how hard the thinking tasks have become. Nearby steps look alike.
decline pathway
For a clinician. A published sequence of cascade tiers that a group can follow over time. It is a group pattern.
For a general reader. A common route that a group of scores can take as they get worse.
consensus molecular subtype (CMS)
For a clinician. A gene-expression class for colorectal cancer (CMS1 to CMS4). The 62-gene panel paper uses this system.
For a general reader. A label for how a bowel cancer looks in its genes. Doctors use the label to group similar tumours.
amyloid-tau-neurodegeneration (ATN) framework
For a clinician. A biomarker scheme that marks amyloid (A), tau (T), and neurodegeneration (N) as positive or negative.
For a general reader. A three-part blood or scan checklist for Alzheimer biology: amyloid, tau, and brain-cell loss.
combining batches (ComBat) harmonization
For a clinician. A statistical method that reduces scanner or batch effects while it keeps biological contrast.
For a general reader. A way to make measurements from different machines more comparable.
electronic fetal monitoring (EFM)
For a clinician. Recording fetal heart rate and uterine contractions to assess fetal well-being during labour.
For a general reader. A monitor tracks the baby's heartbeat and contractions during labour.
hazard ratio (HR)
For a clinician. The ratio of event hazards between groups in a time-to-event analysis.
For a general reader. A comparison of how quickly an event occurs in two groups among people who have not yet had it.
real-world evidence (RWE)
For a clinician. Clinical evidence derived from analysis of routinely collected health data.
For a general reader. What routine healthcare records can tell us about care and its outcomes.