Glossary

Discuss a collaboration

Terms used on this site.

Montreal Cognitive Assessment (MoCA)

For a clinician. A brief bedside screen of attention, memory, language, visuospatial skill, and orientation. Clinicians use the total and domain scores as a screen.

For a general reader. A short set of thinking tasks. A lower score means more trouble with those tasks.

mild cognitive impairment (MCI)

For a clinician. A clinical syndrome: cognitive decline beyond typical aging, with largely preserved independence.

For a general reader. A person notices more thinking trouble than before, but still handles most daily life. Some people later develop dementia.

cascade tier

For a clinician. An ordered severity band in the published cascade analysis. Tiers group similar domain profiles for progression models.

For a general reader. A step on a ladder of how hard the thinking tasks have become. Nearby steps look alike.

decline pathway

For a clinician. A published sequence of cascade tiers that a group can follow over time. It is a group pattern.

For a general reader. A common route that a group of scores can take as they get worse.

consensus molecular subtype (CMS)

For a clinician. A gene-expression class for colorectal cancer (CMS1 to CMS4). The 62-gene panel paper uses this system.

For a general reader. A label for how a bowel cancer looks in its genes. Doctors use the label to group similar tumours.

amyloid-tau-neurodegeneration (ATN) framework

For a clinician. A biomarker scheme that marks amyloid (A), tau (T), and neurodegeneration (N) as positive or negative.

For a general reader. A three-part blood or scan checklist for Alzheimer biology: amyloid, tau, and brain-cell loss.

combining batches (ComBat) harmonization

For a clinician. A statistical method that reduces scanner or batch effects while it keeps biological contrast.

For a general reader. A way to make measurements from different machines more comparable.

electronic fetal monitoring (EFM)

For a clinician. Recording fetal heart rate and uterine contractions to assess fetal well-being during labour.

For a general reader. A monitor tracks the baby's heartbeat and contractions during labour.

hazard ratio (HR)

For a clinician. The ratio of event hazards between groups in a time-to-event analysis.

For a general reader. A comparison of how quickly an event occurs in two groups among people who have not yet had it.

real-world evidence (RWE)

For a clinician. Clinical evidence derived from analysis of routinely collected health data.

For a general reader. What routine healthcare records can tell us about care and its outcomes.

Discuss a collaboration